{
    "Entity": {
        "Name": "levonorgestrel",
        "SMILES": "CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34",
        "Synonyms": [
            "(-)-13-ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one",
            "(8r,9s,10r,13s,14s,17r)-13-ethyl-17-ethynyl-17-hydroxy- 1,2,6,7,8,9,10,11,12,13,14,15,16, 17- tetradecahydrocyclopenta[a] phenanthren-3-one",
            "13-beta-ethyl-17alpha-ethynyl-17beta-hydroxygon-4-en-3-one",
            "13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one",
            "13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one",
            "17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one",
            "17-alpha-ethynyl-13-ethyl-19-nortestosterone",
            "17-ethynyl-18-methyl-19-nortestosterone",
            "17alpha-ethynyl-13beta-ethyl-3-oxo-4-estren-17beta-ol",
            "17alpha-ethynyl-17-hydroxy-18-methylestr-4-en-3-one",
            "17alpha-ethynyl-18-homo-19-nortestosterone",
            "18-methyl-17-alpha-ethynyl-19-nortestosterone",
            "18-methylnorethisterone",
            "d(-)-norgestrel",
            "l\u00e8vonorgestrel",
            "levonorgestrel",
            "levonorgestrelum"
        ],
        "Accession": "DB00367",
        "InChI_key": "WWYNJERNGUHSAO-XUDSTZEESA-N"
    },
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                    "Accession": "C0020624"
                }
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "premenstrual syndrome",
                    "Accession": "C0033046"
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            "Association_type": "side effects"
        },
        {
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                {
                    "Name": "toothache",
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            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "menstruation delayed",
                    "Accession": "C0240322"
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "blood glucose increased",
                    "Accession": "C0595877"
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            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "dermatitis contact",
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "pruritus genital",
                    "Accession": "C0033777"
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            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "tendonitis",
                    "Accession": "C0039503"
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        {
            "Term": [
                {
                    "Name": "sciatica",
                    "Accession": "C0036396"
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            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "medical device complication",
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "breast cancer",
                    "Accession": "C0678222"
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            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "abdominal pain lower",
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            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "menometrorrhagia",
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            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "benign breast neoplasm",
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            "Association_type": "side effects"
        },
        {
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                {
                    "Name": "acute tonsillitis",
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "mastitis",
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            "Association_type": "side effects"
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        {
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                {
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                    "Accession": "C0149741"
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            "Association_type": "side effects"
        },
        {
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                {
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            "Association_type": "side effects"
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        {
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                {
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            "Association_type": "side effects"
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            "Association_type": "side effects"
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        {
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            "Association_type": "side effects"
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        {
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                {
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                {
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            "Association_type": "side effects"
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        {
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        {
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                {
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            "Association_type": "side effects"
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                {
                    "Name": "breast discomfort",
                    "Accession": "C0877338"
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                {
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            "Association_type": "side effects"
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        {
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                {
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        {
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        {
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            "Association_type": "side effects"
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                    "Name": "EGR1",
                    "Accession": "1958"
                }
            ],
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        },
        {
            "Term": [
                {
                    "Name": "EGF",
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        },
        {
            "Term": [
                {
                    "Name": "DCN",
                    "Accession": "1634"
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
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        },
        {
            "Term": [
                {
                    "Name": "CYP3A7",
                    "Accession": "1551"
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
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                    "Name": "CYP3A4",
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
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                    "Name": "CYP2C8",
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
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        },
        {
            "Term": [
                {
                    "Name": "CYP2B6",
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
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            "Term": [
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
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        {
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            "Association_type": "genes"
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            "Term": [
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            "Term": [
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                    "Name": "CX3CR1",
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        {
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                    "Name": "CX3CL1",
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            "Association_type": "genes"
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        {
            "Term": [
                {
                    "Name": "CTSD",
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        {
            "Term": [
                {
                    "Name": "CTNNB1",
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        {
            "Term": [
                {
                    "Name": "CSF1",
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        {
            "Term": [
                {
                    "Name": "COMT",
                    "Accession": "1312"
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "COL1A1",
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "CEBPB",
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            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "CDH1",
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "CD44",
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "CD40LG",
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
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        {
            "Term": [
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                    "Name": "CD34",
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            "Association_type": "genes"
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        {
            "Term": [
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                    "Name": "CCR3",
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            "Association_type": "genes"
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        {
            "Term": [
                {
                    "Name": "CCR2",
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                {
                    "Name": "CCL8",
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            "Term": [
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                    "Name": "CCL7",
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            "Term": [
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                    "Name": "CCL13",
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        {
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                {
                    "Name": "BMP2",
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            "Association_type": "genes"
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        {
            "Term": [
                {
                    "Name": "AR",
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        {
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                    "Name": "ALDH3A1",
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        {
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                {
                    "Name": "ALDH1A1",
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            "Association_type": "genes"
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            "Term": [
                {
                    "Name": "AKR1C3",
                    "Accession": "8644"
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
            "Association_type": "genes"
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        {
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                {
                    "Name": "AKR1C2",
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                    "Name": "AHR",
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            "Association_type": "genes"
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            "Filename": "Geneshot_predicted_generif_drugsetlibrary",
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                    "Name": "polymeric cytoskeletal fiber (GO:0099513)",
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        {
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        {
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        {
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            "Association_type": "Gene Ontology terms"
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        {
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                    "Name": "kinesin complex (GO:0005871)",
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            "Association_type": "Gene Ontology terms"
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        {
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        {
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        {
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        {
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            "Association_type": "Gene Ontology terms"
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        {
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            "Association_type": "Gene Ontology terms"
        },
        {
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                    "Name": "spindle midzone (GO:0051233)",
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            "Association_type": "Gene Ontology terms"
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        {
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                    "Name": "estrogen receptor agonist"
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            "Association_type": "mechanisms of action"
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        {
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            "Association_type": "chemical structure motifs"
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        {
            "Term": [
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            "Association_type": "chemical structure motifs"
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        {
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            "Association_type": "chemical structure motifs"
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        {
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            "Association_type": "chemical structure motifs"
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        {
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            "Association_type": "chemical structure motifs"
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        {
            "Term": [
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                    "Name": "MACCS105",
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            "Association_type": "chemical structure motifs"
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        {
            "Term": [
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                    "Name": "MACCS108",
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            "Association_type": "chemical structure motifs"
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        {
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        {
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            "Association_type": "chemical structure motifs"
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        {
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        {
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            "Association_type": "chemical structure motifs"
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        {
            "Term": [
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                    "Name": "MACCS127",
                    "Accession": "A$A!O > 1 (&...)"
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        {
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        {
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            "Association_type": "chemical structure motifs"
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        {
            "Term": [
                {
                    "Name": "MACCS132",
                    "Accession": "OACH2A"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS139",
                    "Accession": "OH"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS143",
                    "Accession": "A$A!O"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS145",
                    "Accession": "6M RING > 1"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS147",
                    "Accession": "ACH2CH2A"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS150",
                    "Accession": "A!A$A!A"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS152",
                    "Accession": "OC(C)C"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS154",
                    "Accession": "C=O"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS155",
                    "Accession": "A!CH2!A"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS157",
                    "Accession": "C-O"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS159",
                    "Accession": "O > 1"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS160",
                    "Accession": "CH3"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS163",
                    "Accession": "6M RING"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS164",
                    "Accession": "O"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "MACCS165",
                    "Accession": "RING"
                }
            ],
            "Filename": "RDKIT_maccs_fingerprints_drugsetlibrary",
            "Association_type": "chemical structure motifs"
        },
        {
            "Term": [
                {
                    "Name": "negative regulation of cellular macromolecule biosynthetic process (GO:2000113)",
                    "Accession": "GO:2000113"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "positive regulation of cell proliferation (GO:0008284)",
                    "Accession": "GO:0008284"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of cell proliferation (GO:0042127)",
                    "Accession": "GO:0042127"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "DNA metabolic process (GO:0006259)",
                    "Accession": "GO:0006259"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "G1/S transition of mitotic cell cycle (GO:0000082)",
                    "Accession": "GO:0000082"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "cell cycle G1/S phase transition (GO:0044843)",
                    "Accession": "GO:0044843"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of apoptotic process (GO:0042981)",
                    "Accession": "GO:0042981"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "DNA replication (GO:0006260)",
                    "Accession": "GO:0006260"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "cellular macromolecule biosynthetic process (GO:0034645)",
                    "Accession": "GO:0034645"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of signal transduction (GO:0009966)",
                    "Accession": "GO:0009966"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "positive regulation of cellular biosynthetic process (GO:0031328)",
                    "Accession": "GO:0031328"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic cell cycle phase transition (GO:0044772)",
                    "Accession": "GO:0044772"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of cytokinesis (GO:0032465)",
                    "Accession": "GO:0032465"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of cell cycle (GO:0051726)",
                    "Accession": "GO:0051726"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of mitotic cell cycle (GO:0007346)",
                    "Accession": "GO:0007346"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic sister chromatid segregation (GO:0000070)",
                    "Accession": "GO:0000070"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of cell cycle G2/M phase transition (GO:1902749)",
                    "Accession": "GO:1902749"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic spindle organization (GO:0007052)",
                    "Accession": "GO:0007052"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic nuclear division (GO:0140014)",
                    "Accession": "GO:0140014"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "spindle assembly checkpoint (GO:0071173)",
                    "Accession": "GO:0071173"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic spindle assembly checkpoint (GO:0007094)",
                    "Accession": "GO:0007094"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic spindle checkpoint (GO:0071174)",
                    "Accession": "GO:0071174"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "microtubule cytoskeleton organization involved in mitosis (GO:1902850)",
                    "Accession": "GO:1902850"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)",
                    "Accession": "GO:0072431"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "G2/M transition of mitotic cell cycle (GO:0000086)",
                    "Accession": "GO:0000086"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "cell cycle G2/M phase transition (GO:0044839)",
                    "Accession": "GO:0044839"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "DNA repair (GO:0006281)",
                    "Accession": "GO:0006281"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic cytokinesis (GO:0000281)",
                    "Accession": "GO:0000281"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "positive regulation of mitotic cell cycle phase transition (GO:1901992)",
                    "Accession": "GO:1901992"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "DNA damage response, signal transduction by p53 class mediator (GO:0030330)",
                    "Accession": "GO:0030330"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:0006977)",
                    "Accession": "GO:0006977"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of mitotic sister chromatid separation (GO:0010965)",
                    "Accession": "GO:0010965"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "cytoskeleton-dependent cytokinesis (GO:0061640)",
                    "Accession": "GO:0061640"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "negative regulation of cellular amide metabolic process (GO:0034249)",
                    "Accession": "GO:0034249"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of mitotic metaphase/anaphase transition (GO:0030071)",
                    "Accession": "GO:0030071"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic spindle assembly (GO:0090307)",
                    "Accession": "GO:0090307"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "establishment of chromosome localization (GO:0051303)",
                    "Accession": "GO:0051303"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886)",
                    "Accession": "GO:0019886"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "antigen processing and presentation of exogenous peptide antigen (GO:0002478)",
                    "Accession": "GO:0002478"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "antigen processing and presentation of peptide antigen via MHC class II (GO:0002495)",
                    "Accession": "GO:0002495"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "DNA ligation (GO:0006266)",
                    "Accession": "GO:0006266"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "mitotic spindle elongation (GO:0000022)",
                    "Accession": "GO:0000022"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "DNA strand elongation involved in DNA replication (GO:0006271)",
                    "Accession": "GO:0006271"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "negative regulation of cellular protein metabolic process (GO:0032269)",
                    "Accession": "GO:0032269"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of cell cycle process (GO:0010564)",
                    "Accession": "GO:0010564"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "positive regulation of cytokinesis (GO:0032467)",
                    "Accession": "GO:0032467"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "cellular response to DNA damage stimulus (GO:0006974)",
                    "Accession": "GO:0006974"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "positive regulation of macromolecule biosynthetic process (GO:0010557)",
                    "Accession": "GO:0010557"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "regulation of translation (GO:0006417)",
                    "Accession": "GO:0006417"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "centromere complex assembly (GO:0034508)",
                    "Accession": "GO:0034508"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "metaphase plate congression (GO:0051310)",
                    "Accession": "GO:0051310"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "tetrahydrofolate metabolic process (GO:0046653)",
                    "Accession": "GO:0046653"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "CENP-A containing nucleosome assembly (GO:0034080)",
                    "Accession": "GO:0034080"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "CENP-A containing chromatin organization (GO:0061641)",
                    "Accession": "GO:0061641"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "chromatin remodeling at centromere (GO:0031055)",
                    "Accession": "GO:0031055"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "positive regulation of cell cycle G2/M phase transition (GO:1902751)",
                    "Accession": "GO:1902751"
                }
            ],
            "Filename": "L1000FWD_GO_Biological_Processes_drugsetlibrary_down",
            "Association_type": "Gene Ontology terms"
        },
        {
            "Term": [
                {
                    "Name": "ZAR1",
                    "Accession": "326340"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "XCL1",
                    "Accession": "6375"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "WNT4",
                    "Accession": "54361"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "VSIG4",
                    "Accession": "11326"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "VCAM1",
                    "Accession": "7412"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "UGT2B17",
                    "Accession": "7367"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "UGT2B15",
                    "Accession": "7366"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "UBE2C",
                    "Accession": "11065"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "TIMP4",
                    "Accession": "7079"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "TIMP3",
                    "Accession": "7078"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "TIMP2",
                    "Accession": "7077"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "TIMP1",
                    "Accession": "7076"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "THRA",
                    "Accession": "7067"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "THBS2",
                    "Accession": "7058"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "TGM4",
                    "Accession": "7047"
                }
            ],
            "Filename": "Geneshot_predicted_autorif_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "TGM2",
                    "Accession": "7052"
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        {
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        {
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        {
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        {
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        {
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        {
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                {
                    "Name": "ovarian cyst torsion",
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        {
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        {
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        {
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        {
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        {
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                {
                    "Name": "meningorrhagia",
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            "Association_type": "side effects"
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        {
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                {
                    "Name": "colitis erosive",
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            "Association_type": "side effects"
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        {
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                {
                    "Name": "incision site abscess",
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            "Association_type": "side effects"
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        {
            "Term": [
                {
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        {
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                {
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        {
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                {
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            "Association_type": "side effects"
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        {
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                {
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "body height increased",
                    "Accession": "C0231249"
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "uterine contractions abnormal",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "sports injury",
                    "Accession": "C0004161"
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "dacryostenosis congenital",
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "no reaction on previous exposure to drug",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "histone antibody positive",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "postoperative adhesion",
                    "Accession": "C0001510"
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "pelvic infection",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "pyometra",
                    "Accession": "C0034215"
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "sexually transmitted disease",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "uterine infection",
                    "Accession": "C0042136"
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "uterine perforation",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "biliary adenoma",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "uterine tenderness",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
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        {
            "Term": [
                {
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
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        {
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                {
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
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        {
            "Term": [
                {
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "ovarian abscess",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "sarcoma uterus",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "ectopic pregnancy termination",
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        },
        {
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                {
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
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            "Association_type": "side effects"
        },
        {
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                {
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
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        {
            "Term": [
                {
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "mechanical complication of implant",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "ovarian adenoma",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
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        {
            "Term": [
                {
                    "Name": "hydrometra",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "uterine cyst",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "urine human chorionic gonadotropin increased",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "streptococcal serology",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "pregnancy with contraceptive device",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "uterine haematoma",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
                    "Name": "post procedural pulmonary embolism",
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            "Filename": "PharmGKB_OFFSIDES_side_effects_drugsetlibrary",
            "Association_type": "side effects"
        },
        {
            "Term": [
                {
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            "Association_type": "side effects"
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        {
            "Term": [
                {
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            "Association_type": "side effects"
        },
        {
            "Term": [
                {
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            "Association_type": "side effects"
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        {
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        {
            "Term": [
                {
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        },
        {
            "Term": [
                {
                    "Name": "SLC6A4",
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            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "ESR1",
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        },
        {
            "Term": [
                {
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        {
            "Term": [
                {
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        },
        {
            "Term": [
                {
                    "Name": "SHBG",
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            "Filename": "DrugCentral_target_drugsetlibrary",
            "Association_type": "genes"
        },
        {
            "Term": [
                {
                    "Name": "Human T-cell leukemia virus 1 infection",
                    "Accession": "map05166"
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        },
        {
            "Term": [
                {
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "Pathways in cancer",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "PI3K-Akt signaling pathway",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
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        },
        {
            "Term": [
                {
                    "Name": "Cell cycle",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "DNA replication",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "Bladder cancer",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "p53 signaling pathway",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "Mismatch repair",
                    "Accession": "map03430"
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "Central carbon metabolism in cancer",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "MicroRNAs in cancer",
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            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        },
        {
            "Term": [
                {
                    "Name": "One carbon pool by folate",
                    "Accession": "map00670"
                }
            ],
            "Filename": "L1000FWD_KEGG_Pathways_drugsetlibrary_down",
            "Association_type": "KEGG pathways"
        }
    ]
}